EFFECT OF 1, 25 DIHYDROXYCHOLECALCIFEROL (1, 25 D3) ON LEUKOCYTE GAMMA GLUTAMYL TRANSPEPTIDASE (GGTP)
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چکیده
منابع مشابه
1α,25-Dihydroxyvitamin D3 enhances γ-glutamyl transpeptidase activity in LLC-PK1 porcine kidney epithelial cells.
Mammalian γ-glutamyl transpeptidase (GGT) is expressed most highly in the kidney and serves to recover the constituent amino acids of glutathione in the proximal tubules. Serum GGT is used as a marker for obstructive jaundice and alcoholic liver disease and it has been reported that urinary GGT is a potential marker for bone resorption. The present study investigated the effect of derivatives o...
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25-Hydroxyvitamin D3-1 -hydroxylase (25(OH)D3-1 -hydroxylase), the key enzyme of 1 ,25-dihydroxyvitamin D3 (1,25(OH)2D3) production, is expressed in monocyte-derived macrophages (MACs). Here we show for the first time constitutive expression of 25(OH)D3-1 -hydroxylase in monocyte-derived dendritic cells (DCs), which was increased after stimulation with lipopolysaccharide (LPS). Accordingly, DCs...
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Serum gamma-glutamyl transpeptidase ( G G T ), alkaline phosphatase (A L P ) and aspartate aminotransferase (A ST) were assayed in patients with cancer. GGT was more sensitive than either ALP or AST in detecting metastatic car cinoma to the liver in both icteric and anicteric patients with cancer. Extremely high activities of GGT were seen in patients with hepatoma, carcinoma of the pancreas a...
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Introduction The enzyme gamma-glutamyl transpeptidase (GGT)* is widely used as a marker in preneoplastic lesions in the liver during chemical carcinogenesis (1). The discovery of a link between GGT and liver carcinogenesis first occurred in 1972 when Fiala and co-workers reported elevated levels of the enzyme in livers of rats fed the hepatocarcinogen 3'-methyl-4dimethylaminoazobenzene and also...
متن کاملThe influence of gestational dietary calcium on serum 1, 25-dihydroxycholecalciferol in sows and their pigs.
Fifteen multiparous sows (three groups of five) were studied during one gestation-lactation cycle to measure the influence of dietary Ca (.5, .8[control], and 1.1%) on 1,25-dihydroxycholecalciferol (1, 25-(OH)2D3) in serum and colostrum of the sows and serum of their pigs. Concentrations of 1,25-(OH)2D3 and Ca, Mg, P, Cu, and Zn were determined on d 15 and 45 of gestation, at parturition, and a...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 1984
ISSN: 0031-3998,1530-0447
DOI: 10.1203/00006450-198404001-01179